Day of the Tentacle is the sequel to Maniac Mansion (which you can actually play within DotT) and one of the funniest point & click adventures I've had the pleasure to stumble puzzle through.

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A lot of people that read this today might not have been old enough to to play Day of the Tentacle when it released back in 1993, I certainly wasn't. When I finally did get around to it I found a game with extremely funny dialogue and even better voice acting, truly one of LucasArts